Two sample MR report
GBP3_Alveolar Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 18 | 0.0141531 | 0.0287324 | 0.6289987 |
| Weighted median | 18 | -0.0105495 | 0.0048464 | 0.0294970 |
| Inverse variance weighted | 18 | -0.0100437 | 0.0036471 | 0.0058890 |
| Simple mode | 18 | -0.0149000 | 0.0076346 | 0.0676555 |
| Weighted mode | 18 | -0.0118821 | 0.0079370 | 0.1527148 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 9.342314 | 16 | 0.8986496 |
| Inverse variance weighted | 10.063130 | 17 | 0.9009420 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0196828 | 0.0231832 | 0.4083999 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0004943 | 0 | TRUE | 0.0344669 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
